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ASCP MEDICAL LABORATORY TECHNICIAN - MLT(ASCP) Sample Questions:

1. Since cimetidine inhibits CYP2D6, less amphetamine will probably need to be given since it will not be able to be metabolized as readily.
Most drug interactions are like this: one drug inhibits or competes with the same CYP450 as another drug. The end result is that higher concentrations of one, or both, drugs are present, leading to potential toxicity.
A patient is taking cimetidine for a stomach ulcer. This drug inhibits CYP2D6. The patient is now prescribed amphetamine for narcolepsy. Amphetamine is metabolized by CYP2D6. What would you predict?

A) Nothing can be assumed until you know the patient's status (PM, EM, UM).
B) The two drugs can never be given together since they interact.
C) The dose for amphetamine needs to be higher than normal.
D) The dose for the amphetamine needs to be lower than normal.

2. Antidiuretic hormone, or ADH, has the important role of conserving body water by reducing the loss of water in urine by changing the water permeability of the distal tubule and collecting duct. An increase in ADH causes a concentrated urine since the water is retained and absorbed through the permeable membrane. An decrease in ADH causes the collecting ducts to retain very little water, instead it is excreted as urine.
Chemistry
Which of the following action describes the MAJOR property of antidiuretic hormone?

A) controls thirst
B) cannot be affected by diuretics
C) changes distal tubule water permeability
D) Acts on Na/K/(H') pump
E) acts on proximal tubules.

3. Enterococcus spp. are bile esculin positive and grow in 6.5% NaCl. If they grow on the 6 µg/mL vancomycin screen agar as this isolate does, it is vancomycin resistant. If there is no growth on the 6 µg/mL vancomycin screen agar, the isolate is susceptible to vancomycin. Streptococcus Group D, not Enterococcus will not grow in the 6.5% NaCl and should not be tested for vancomycin resistance. Staphylococcus epidermidis is catalase positive.

The images below represent a gram-positive, catalase-negative, non-motile coccus inoculated to bile esculin agar, 6.5% NaCl broth and to 6 µg/mL of vancomycin in Mueller Hinton agar. It should be reported as:

A) Enterococcus spp., Susceptible to vancomycin
B) Enterococcus spp., Resistant to vancomycin
C) Staphylococcus epidermidis, Resistant to vancomycin
D) Streptococcus Group D, not Enterococcus

4. Provide the equivalent measurement for 1 ounce.

A) 5.7 grams
B) 28.35 grams
C) 100 grams
D) 10 grams

5. The molecular weight of a hapten is by itself not sufficient to elicit an antibody response alone, but requires a protein to do so.
A hapten is only antigenic when it is coupled with which of the following:

A) Enzymes
B) Proteins
C) Lymphocytes
D) Lipids

Solutions: